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Wei-Wen Kuo Selected Research

Glucose (Dextrose)

10/2021Diallyl Trisulfide Suppresses High-Glucose-Induced Cardiomyocyte Apoptosis by Targeting Reactive Oxygen Species-Mediated Hypoxia-Inducible Factor-1α/Insulin-like Growth Factor Binding Protein 3 Activation.
1/2021Antioxidant Sirt1/Akt axis expression in resveratrol pretreated adipose-derived stem cells increases regenerative capability in a rat model with cardiomyopathy induced by diabetes mellitus.
4/2020Diallyl Trisulfide (DATS) Suppresses AGE-Induced Cardiomyocyte Apoptosis by Targeting ROS-Mediated PKCδ Activation.
1/2018Synergistic effect of HIF-1α and FoxO3a trigger cardiomyocyte apoptosis under hyperglycemic ischemia condition.
1/2016Palmitic acid interferes with energy metabolism balance by adversely switching the SIRT1-CD36-fatty acid pathway to the PKC zeta-GLUT4-glucose pathway in cardiomyoblasts.
1/2015Tetramethylpyrazine Ameliorated Hypoxia-Induced Myocardial Cell Apoptosis via HIF-1α/JNK/p38 and IGFBP3/BNIP3 Inhibition to Upregulate PI3K/Akt Survival Signaling.
9/2013Antioxidant effects of diallyl trisulfide on high glucose-induced apoptosis are mediated by the PI3K/Akt-dependent activation of Nrf2 in cardiomyocytes.
9/2013Diallyl trisufide (DATS) suppresses high glucose-induced cardiomyocyte apoptosis by inhibiting JNK/NFκB signaling via attenuating ROS generation.

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Wei-Wen Kuo Research Topics

Disease

41Cardiomegaly (Heart Hypertrophy)
01/2024 - 11/2004
40Neoplasms (Cancer)
12/2023 - 07/2006
40Hypertrophy
02/2022 - 11/2004
31Fibrosis (Cirrhosis)
03/2024 - 10/2005
25Inflammation (Inflammations)
05/2024 - 05/2006
23Hypoxia (Hypoxemia)
01/2023 - 03/2007
19Hypertension (High Blood Pressure)
12/2022 - 01/2004
16Heart Failure
01/2024 - 05/2006
14Cardiomyopathies (Cardiomyopathy)
03/2024 - 10/2010
12Diabetic Cardiomyopathies
03/2024 - 01/2011
11Heart Diseases (Heart Disease)
11/2023 - 10/2005
11Hyperglycemia
03/2023 - 04/2012
11Colonic Neoplasms (Colon Cancer)
01/2023 - 04/2006
11Hepatocellular Carcinoma (Hepatoma)
01/2022 - 10/2006
10Cardiotoxicity
12/2023 - 09/2016
10Cardiovascular Diseases (Cardiovascular Disease)
01/2021 - 10/2009
9Colorectal Neoplasms (Colorectal Cancer)
12/2023 - 04/2006
9Mitochondrial Diseases (Mitochondrial Disease)
12/2023 - 02/2015
9Neoplasm Metastasis (Metastasis)
01/2018 - 09/2006
8Wounds and Injuries (Trauma)
12/2023 - 01/2016
7Body Weight (Weight, Body)
09/2021 - 02/2003
6Lung Neoplasms (Lung Cancer)
12/2023 - 01/2021
6Myocardial Infarction
06/2019 - 05/2008
6Obesity
01/2019 - 10/2007
5Necrosis
03/2023 - 03/2007
5Parkinson Disease (Parkinson's Disease)
01/2023 - 11/2010
4Melanoma (Melanoma, Malignant)
05/2024 - 12/2019
4Hemorrhagic Shock
12/2023 - 06/2015
4Diabetes Mellitus
01/2021 - 09/2015
4Carcinogenesis
12/2019 - 11/2014
4Hyperlipidemias (Hyperlipidemia)
01/2019 - 01/2016
3Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
12/2023 - 05/2009
3Rheumatoid Arthritis
10/2022 - 05/2006

Drug/Important Bio-Agent (IBA)

51Proteins (Proteins, Gene)FDA Link
12/2023 - 01/2005
16Angiotensin IIIBA
12/2022 - 07/2006
14CalcineurinIBA
02/2022 - 12/2005
14Insulin-Like Growth Factor II (Somatomedin A)IBA
12/2021 - 07/2006
13Reactive Oxygen Species (Oxygen Radicals)IBA
01/2024 - 04/2012
12Estrogen ReceptorsIBA
09/2023 - 07/2006
11Doxorubicin (Adriamycin)FDA LinkGeneric
12/2023 - 09/2016
11Insulin-Like Growth Factor I (IGF-1)IBA
11/2023 - 09/2005
11Atrial Natriuretic Factor (ANF)IBA
10/2019 - 11/2004
10Insulin-Like PeptidesIBA
12/2023 - 05/2006
10IGF Type 2 Receptor (Insulin-Like-Growth-Factor II Receptor)IBA
09/2023 - 07/2006
10CollagenIBA
11/2022 - 01/2011
9Matrix Metalloproteinases (MMPs)IBA
11/2023 - 05/2006
8Estrogens (Estrogen)FDA Link
01/2023 - 09/2006
8Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA
01/2022 - 05/2008
8Glucose (Dextrose)FDA LinkGeneric
10/2021 - 09/2013
8Streptozocin (Streptozotocin)FDA Link
09/2021 - 10/2010
7Phosphotransferases (Kinase)IBA
12/2021 - 05/2009
6Sirtuin 1IBA
12/2023 - 01/2018
6Transcription Factors (Transcription Factor)IBA
11/2022 - 06/2008
5Therapeutic UsesIBA
03/2024 - 02/2013
5TeaIBA
03/2024 - 03/2014
5MicroRNAs (MicroRNA)IBA
12/2023 - 01/2018
5AntioxidantsIBA
12/2023 - 09/2013
5GemcitabineFDA Link
12/2023 - 01/2021
5LipidsIBA
01/2023 - 04/2006
5Advanced Glycation End ProductsIBA
08/2022 - 08/2018
5Mitogen-Activated Protein KinasesIBA
02/2022 - 04/2005
5Hematoxylin (Haematoxylon)IBA
01/2022 - 10/2007
5Eosine Yellowish-(YS) (Eosin)IBA
01/2022 - 10/2007
5CateninsIBA
09/2019 - 08/2011
5Brain Natriuretic Peptide (Natrecor)FDA Link
01/2019 - 05/2008
4epigallocatechin gallate (epigallocatechin-3-gallate)IBA
03/2024 - 11/2017
4Irinotecan (Camptosar)FDA LinkGeneric
12/2023 - 07/2014
4Growth Hormone (Somatotropin)IBA
11/2023 - 05/2006
4Phytoestrogens (Phytoestrogen)IBA
09/2023 - 09/2016
4CytokinesIBA
08/2023 - 05/2009
4Oxaliplatin (Eloxatin)FDA LinkGeneric
01/2023 - 01/2018
4Protein Kinases (Protein Kinase)IBA
02/2022 - 04/2005
4Histone Deacetylase InhibitorsIBA
01/2022 - 01/2014
4diallyl trisulfideIBA
10/2021 - 02/2013
4Insulin-Like Growth Factor Binding Protein 3IBA
10/2021 - 01/2015
4Protein Phosphatase 1IBA
11/2020 - 04/2017
4Galactose (Galactopyranose)FDA LinkGeneric
01/2020 - 03/2016
4transcription factor NF-AT c3IBA
11/2019 - 01/2015
4Urokinase-Type Plasminogen Activator (Urokinase)FDA Link
06/2019 - 05/2009
4Plasminogen Activators (Plasminogen Activator)IBA
06/2019 - 05/2009
4CholesterolIBA
11/2017 - 09/2009
4Apoptosis Regulatory ProteinsIBA
01/2017 - 04/2008
4Tobacco Smoke Pollution (Passive Smoking)IBA
09/2016 - 10/2005
4Transforming Growth Factor beta (TGF-beta)IBA
05/2016 - 11/2004
4Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2016 - 03/2007
4Death Domain ReceptorsIBA
09/2009 - 10/2005
3FlavonoidsIBA
12/2023 - 06/2019
3Biomarkers (Surrogate Marker)IBA
11/2023 - 02/2009
3fisetinIBA
09/2023 - 06/2019
37,3'-dihydroxy-4'-methoxyisoflavoneIBA
07/2023 - 04/2022
3Prolyl Hydroxylases (Prolyl Hydroxylase)IBA
01/2023 - 01/2019
3ParaquatIBA
01/2023 - 07/2019
3Fatty Acids (Saturated Fatty Acids)IBA
01/2023 - 01/2016
3LipopolysaccharidesIBA
01/2023 - 06/2008
3InterleukinsIBA
11/2022 - 05/2006
3Arecoline (Arecolin)IBA
02/2022 - 04/2013

Therapy/Procedure

22Therapeutics
12/2023 - 04/2006
9Drug Therapy (Chemotherapy)
12/2023 - 07/2014
6Oral Administration
07/2021 - 06/2013
4Transplantation
01/2022 - 11/2017